Toolkit Modules:

1. Disease Overview
2. Pathology of Castleman Disease
3. Clinical Manifestations
4. Important Differential Diagnoses
5. Case Studies

The diagnosis of Castleman disease is a diagnosis of exclusion. The most relevant differential diagnoses can be case specific, weighing various clinical factors against histopathological findings. More specific differential diagnostic criteria are covered in the Case Studies section of this toolkit. However, the following are common diseases which are to be excluded when Castleman disease is suspected:

  • Follicular hyperplasia
  • Follicular lymphoma
  • HIV lymphadenopathy
  • Mantle cell lymphoma
  • Progressive transformation of germinal centers