New Research Pipeline

CDCN’s Ground-breaking Collaborative Network Approach

Build Community

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Crowdsource and Study Prioritization

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Identify researchers

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Fundraising

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Sample Procurement

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Study Execution

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Data analysis and search for new treatments based on results

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Disseminate Knowledge

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1) What causes Castleman disease and the immune system to become activated and release cytokines?

HUNT (Hunting for an Unknown, Novel Trigger)

Study E-100

Cost $57,000

Status Funded

Samples have been collected and the study has been performed. Data is currently being analyzed.

Description

We need to understand why the immune system becomes activated in Castleman disease. One hypothesis (idea) about the cause is that a virus or other pathogen triggers the immune system (the body’s defense system against infections) to become activated. The activated immune system releases inflammatory proteins that can cause flu-like symptoms and organ failure. The HUNT study looks at Castleman disease patients’ lymph node samples to “hunt” for the RNA (like a fingerprint) of pathogens. If a virus is cause Castleman disease, we’ll find it. This is also called “viral hunting” or “pathogen discovery.”

Investigators

Dr. Ian Lipkin (PI, Columbia University); co-Investigators: Drs. David Fajgenbaum (UPenn), Jason Ruth (Harvard), & Chris Nabel (Harvard)
See Map of Collaborators

Video