- "VEGF is frequently elevated in iMCD. VEGF, which promotes cell survival, angiogenesis, and vascular permeability, is often elevated in parallel with iMCD symptoms" (blood 2014)
Sirolimus (Rapamycin) is an mTOR inhibitor that blocks VEGF expression by inhibiting mTOR.
- To learn more about sirolimus as treatment for iMCD, please click here.
Clinical Trials targeting VEGF in iMCD:
No clinical trials targeting VEGF in iMCD patients have been conducted.